William Clark Gable was born on February 1, 1901 in Cadiz, Ohio, to Adeline (Hershelman) and William Henry Gable, an oil-well driller. He was of German, Irish, and Swiss-German descent. When he was seven months old, his mother died, and his father sent him to live with his maternal aunt and uncle in Pennsylvania, where he stayed until he was two. His father then returned to take him back to Cadiz. At 16, he quit high school, went to work in an Akron, Ohio, tire factory, and decided to become an actor after seeing the play "The Bird of Paradise". He toured in stock companies, worked oil fields and sold ties. On December 13, 1924, he married Josephine Dillon, his acting coach and 15 years his senior. Around that time, they moved to Hollywood, so that Clark could concentrate on his acting career. In April 1930, they divorced and a year later, he married Maria Langham (a.k.a. Maria Franklin Gable), also about 17 years older than him.

While Gable acted on stage, he became a lifelong friend of Lionel Barrymore. After several failed screen tests (for Barrymore and Darryl F. Zanuck), Gable was signed in 1930 by MGM's Irving Thalberg. He had a small part in The Painted Desert (1931) with starred William Boyd. Joan Crawford asked for him as co-star in Dance, Fools, Dance (1931) and the public loved him manhandling Norma Shearer in A Free Soul (1931) the same year. His unshaven lovemaking with bra-less Jean Harlow in Red Dust (1932) made him MGM's most important star.